Predicting Response to Treatment in Patients With Cancer

Abstract

Many cancer patients receive expensive and unpleasant therapies that actually do not benefit them. This project will use a new technology that can simultaneously assess the level of expression of thousands of genes. We will test if the pattern of gene expression in tumours can predict the patients' response to therapy. Success will significantly improve the clinical management of advanced cancer patients and provide a rational basis upon which to tailor individualized treatment regimes.

Related publications (1)

Pretreatment transcriptional profiling for predicting response to neoadjuvant chemoradiotherapy in rectal adenocarcinoma

KH Brettingham-Moore, CP Duong, DM Greenawalt, AG Heriot, J Ellul, CA Dow, WK Murray, RJ Hicks, J Tjandra, M Chao, A Bui, DL Joon, RJS Thomas, WA Phillips

2011-05-01

Purpose: Patients presenting with locally advanced rectal cancer currently receive preoperative radiotherapy with or without chemo..